RELAZIONI CONGRESSI

Tutti gli articoli sulle Relazioni e i Congressi


MITOCHONDRIAL BIOACTIVE PEPTIDES (MDP) and MOTSC in Cardiovascular Health Inflammaging and Longevity-ANTIAGING MONTECARLO CONGRESS-04/22


MITOCHONDRIAL BIOACTIVE PEPTIDES(MDP) and MOTSC in Cardiovascular Health Inflammaging and Longevity.

Mitochondrial-derived peptides (MDPs) are a novel class of bioactive microproteins that modify cell metabolism. The the eight MDPs that been characterized (e.g., humanin, MOTS-c, SHLPs1-6) attenuate disease pathology including Alzheimer's disease, prostate cancer, macular degeneration, cardiovascular disease, and diabetes. The association between disease and human genetic variation in MDPs is underexplored, although two polymorphisms in humanin and MOTS-c associate with cognitive decline and diabetes, respectively, suggesting a precise role for MDPs in disease-modification. There could be hundreds of additional MDPs that have yet to be discovered. Altogether, MDPs could explain unanswered biological and metabolic questions and are part of a growing field of novel microproteins encoded by small open reading frames. In this review, the current state of MDPs are summarized with an emphasis on biological and therapeutic implications on  antiaging and longevity interventions.
21 Aprile 2022