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ABSTRACT del Congresso Internazionale di Medicina Antiaging di PARIGI(11-12 OTTOBRE2013)


Endocrine aging and inflammation as main pathogenetic factors of aging.


Inflamm-ageing, defined as the chronic low-grade inflammation typical of ageing, seems to be the common biological factor responsible for the decline and the onset of disease in the elderly. The major age-related diseases share a common inflammatory pathogenesis, giving rise to the so-called 'diseasome of inflamm-ageing'. 
In this lecture the main studies about the connection between aging process and inflammaging are reviewed. The effect of the multiendocrine imbalancement aging related on inflammation and of different predictive factors of future activation of chronic low grade in flammation are also explored.
Inflammaging is the result of the chronic interaction among different pathogenetic factors.Among these the endocrinesenescence exerts a key role.Important epidemiological studies have also identified different predictive factors (disnutrition,obesity and sarcopenic obesity,physical inactivity,chronic deseases) that anticipate of many years and activate overtime chronic low grade inflammation that is the common pathway of many age related diseases.
Multiendocrine inbalancemet,adiposity,slower walking speed,higher disease burden,sleep desorders, and chronic antigenic overload,are associated with increased levels of inflammatory markers.The manageing of these factors could be an important strategy in the prevention or slowing of chronic low grade inflammation.

11 Settembre 2013